Two new phenolic compounds from Boerhavia erecta collected in Vietnam

Boerhavia erecta is a tropical plant that is widely used in Asian folk medicine. Little is known about the alpha-glucosidase inhibition and antimicrobial properties of compounds from this plant. In the present study, the phytochemical study of the aerial parts of B. erecta collected in Vietnam was c...

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Published in:Natural product research 2023-10, Vol.37 (20), p.3470-3477
Main Authors: Nguyen, Huu-Hung, Do, Thanh-Hung, Nguyen, Thi-Hoai-Thu, Duong, Thuc-Huy, Vo, Huu-Canh, Do, Van-Mai, Nguyen, Thi-Phuong, Sichaem, Jirapast, Nguyen, Ngoc-Hong, Nguyen, Huy Truong
Format: Article
Language:English
Subjects:
alpha-glucosidase inhibition
Antibiotic resistance
antimicrobial
Antimicrobial activity
boeravinone
Boerhavia erecta
Carboxylic acids
Chromatography
Glucosidase
Indole-3-carboxylic acid
Liquiritigenin
Medicinal plants
Nyctaginaceae
Phenolic compounds
Phenols
rotenoid
Tropical plants
α-Glucosidase
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Summary:Boerhavia erecta is a tropical plant that is widely used in Asian folk medicine. Little is known about the alpha-glucosidase inhibition and antimicrobial properties of compounds from this plant. In the present study, the phytochemical study of the aerial parts of B. erecta collected in Vietnam was conducted using multiple chromatographic methods. The chemical structures of isolated compounds were identified by comprehensive spectroscopic methods. Two new compounds, berectone C (1) and (E)-tetracosyl 3-(3-hydroxy-4-methoxyphenyl)acrylate (4), together with the known compounds boeravinone C (2), liquiritigenin (3), bis(1H-indol-3-yl)methanone (5), and indole-3-carboxylic acid (6) were isolated and structural elucidated. Compounds 1 and 4 were evaluated for alpha-glucosidase inhibition and antimicrobial activity against antibiotic-resistant, pathogenic bacteria Enterococcus faecium, Staphylococcus aureus, and Acinetobacter baumannii. Compound 1 showed strong inhibition of the alpha-glucosidase enzyme (IC 50 43 µg/mL). Only compound 1 exhibited antimicrobial property against A. baumannii, forming an inhibition zone of 11 mm.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2086543