Transmission of canine transmissible venereal tumour between two dogs in the UK

Canine transmissible venereal tumour (CTVT) is a contagious cancer spread by transfer of living cancer cells. Occasional cases are observed in the UK in dogs imported from endemic regions. Here, we report a case of imported canine transmissible venereal tumour that was transmitted to a second dog wi...

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Bibliographic Details
Published in:Journal of small animal practice 2023-09, Vol.64 (9), p.590-594
Main Authors: Hayes, A M, Schiavo, L, Constantino-Casas, F, Desmas, I, Dobson, J, Draper, A, Elliot, J, Genain, M-A, Wang, J, Murchison, E P
Format: Article
Language:English
Subjects:
Animals
Canine transmissible venereal tumor
Case reports
Cytology
Dog Diseases - diagnosis
Dogs
Immunohistochemistry
Metastases
Myc protein
Polymerase Chain Reaction - veterinary
Therapeutic applications
Tumors
United Kingdom
Venereal Tumors, Veterinary - diagnosis
Venereal Tumors, Veterinary - drug therapy
Venereal Tumors, Veterinary - pathology
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Summary:Canine transmissible venereal tumour (CTVT) is a contagious cancer spread by transfer of living cancer cells. Occasional cases are observed in the UK in dogs imported from endemic regions. Here, we report a case of imported canine transmissible venereal tumour that was transmitted to a second dog within the UK. Transmission of genital canine transmissible venereal tumour occurred despite neutered status of the second dog. The aggressive course of disease in both cases, which included metastasis, resistance to therapeutic interventions and ultimate euthanasia of both dogs, is described. The diagnosis of canine transmissible venereal tumour was made using a combination of cytology, histology, immunohistochemistry and PCR to detect the LINE-MYC rearrangement. Practitioners unfamiliar with canine transmissible venereal tumour are reminded of this disease of concern, particularly when imported dogs are placed in multi-dog households, irrespective of neuter status.
ISSN:0022-4510
1748-5827
DOI:10.1111/jsap.13607