Zwitterionic mesoporous engineering aids peptide-dependent pattern profiling for identification of different liver diseases

Liver disease remains a global health challenge, with its incidence steadily increasing worldwide. Herein, zwitterionic mesoporous engineering was developed for the identification of different liver diseases including liver cirrhosis and liver cancer. Based on this engineering, a total of 2633 m / z...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-09, Vol.59 (74), p.1181-1184
Main Authors: Xu, Zixing, Zhang, Wantong, Deng, Chunhui, Sun, Nianrong
Format: Article
Language:English
Subjects:
Peptides
Public health
Zwitterions
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Summary:Liver disease remains a global health challenge, with its incidence steadily increasing worldwide. Herein, zwitterionic mesoporous engineering was developed for the identification of different liver diseases including liver cirrhosis and liver cancer. Based on this engineering, a total of 2633 m / z signals were observed to be enriched. Notably, three key peptides were identified and showed high accuracy and precision for distinguishing the healthy and disease states, propelling the field of nanomedicine toward genuine personalized medicine. Zwitterionic mesoporous engineering was developed to assist high-throughput separation and analysis of peptide patterns. Its further coupling with machine learning achieved a precise diagnosis of different liver diseases.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d3cc03231k