Front Cover: Recent Progress in Asymmetric Domino Intramolecular Cyclization/Cascade Reactions of Substituted Olefins (Chem. Asian J. 18/2023)

The domino cyclization/coupling strategy is one of the most effective methods to produce cyclized and multi‐functionalized compounds from olefins and has attracted considerable attention from chemists and biochemists. Herein, recent advances in the transition metal‐catalyzed asymmetric domino cycliz...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2023-09, Vol.18 (18), p.n/a
Main Authors: Zou, Liang, Gao, Yuan, Zhang, Qiaoman, Ye, Xiang‐Yang, Xie, Tian, Wang, Li‐Wei, Ye, Yang
Format: Article
Language:English
Subjects:
Aldehydes
Alkenes
Asymmetry
Cascade chemical reactions
Cascade reaction
Chemistry
Coupling
Cross-coupling
Domino cyclization
Enantioselective
Olefins
Production methods
Transition metals
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Summary:The domino cyclization/coupling strategy is one of the most effective methods to produce cyclized and multi‐functionalized compounds from olefins and has attracted considerable attention from chemists and biochemists. Herein, recent advances in the transition metal‐catalyzed asymmetric domino cyclization coupling of alkenes with a series of electrophiles are summarized by dividing the reaction types into five categories: domino Heck reaction, tandem radical cyclization, cascade heterometallization, domino cycloisomerizations, and cascade aldol cyclization. The specific conditions, mechanisms and yields of synthesis are provided for representative examples, and the advantages and disadvantages of the various methods are outlined. More information can be found in the Review by Yang Ye, Tian Xie, Li‐Wei Wang et al.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202300721