Design and synthesis of unnatural coordination glycopolymer particles (CGPs): unleashing the potential of catechol-saccharide derivatives

Our study unveils an innovative methodology that merges catechols with mono- and disaccharides, yielding a diverse array of compounds. This strategic fusion achieves robust yields and introduces ligands with a dual nature: encompassing both the chelating attributes of catechols and the recognition c...

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Bibliographic Details
Published in:RSC advances 2023-09, Vol.13 (39), p.27491-275
Main Authors: Bideplán-Moyano, Celina, Lo Fiego, Marcos J, Calmels, Juan José, Alonso, Belén, Radivoy, Gabriel, Ruiz-Molina, Daniel, Mancebo-Aracil, Juan, Nador, Fabiana
Format: Article
Language:English
Subjects:
Aqueous solutions
Carbohydrates
Catechol
Chelation
Chemistry
Coordination
Disaccharides
Freezing
Glycopolymers
Ligands
Molecular structure
Polydispersity
Stability
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Summary:Our study unveils an innovative methodology that merges catechols with mono- and disaccharides, yielding a diverse array of compounds. This strategic fusion achieves robust yields and introduces ligands with a dual nature: encompassing both the chelating attributes of catechols and the recognition capabilities of carbohydrates. This synergistic design led us to couple one of the novel ligands with an Fe( iii ) salt, resulting in the creation of Coordination Glycopolymer Particles (CGPs). These CGPs demonstrate remarkable qualities, boasting outstanding dispersion in both aqueous media and Phosphate Buffered Saline (PBS) solution (pH ∼7.4) at higher concentrations (0.26 mg μL −1 ). Displaying an average Z-size of approximately 55 nm and favourable polydispersity indices (
ISSN:2046-2069
2046-2069
DOI:10.1039/d3ra05316d