A new pharmacological composition based on water-soluble pectin metal complexes stimulating hematopoiesis

New pharmacological compositions based on water-soluble pectin metal complexes PG-NaCaFe and PG-NaFeCoCu (PG is polygalacturonate) in weight ratios of 6: 1, 9: 1, and 12: 1 promising for pharmacology and medicine as drugs for the treatment of both iron deficiency and pernicious anemia are developed....

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Bibliographic Details
Published in:Russian chemical bulletin 2023-09, Vol.72 (9), p.2263-2277
Main Authors: Minzanova, S. T., Chekunkov, E. V., Khabibullina, A. V., Vyshtakalyuk, A. B., Kholin, K. V., Mironova, L. G., Nizameeva, G. R., Khamatgalimov, A. R., Ryzhkina, I. S., Murtazina, L. I., Milyukov, V. A.
Format: Article
Language:English
Subjects:
Anemia
Chemical compounds
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Composition
Coordination compounds
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Hematocrit
Hematopoiesis
In vivo methods and tests
Inorganic Chemistry
Organic Chemistry
Pectin
Pharmaceuticals
Pharmacology
Water chemistry
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Summary:New pharmacological compositions based on water-soluble pectin metal complexes PG-NaCaFe and PG-NaFeCoCu (PG is polygalacturonate) in weight ratios of 6: 1, 9: 1, and 12: 1 promising for pharmacology and medicine as drugs for the treatment of both iron deficiency and pernicious anemia are developed. According to the testing results on males of the Sprague Dawley rat line in vivo , the most pronounced increase in the number of erythrocytes and hematocrit is observed upon the introduction of the composition with the 9: 1 PG-NaCaFe to PG-NaFeCoCu weight ratio indicating the highest efficiency of this complex drug.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-023-4024-6