One‐pot synthesis of 1,8-dioxo-decahydroacridine and hexahydroquinoline derivatives catalyzed by a new natural deep eutectic mixture

In this work, a novel natural deep eutectic mixture was prepared from glucose, pregabalin and urea and identified using a variety of techniques including Fourier transform infrared spectroscopy, thermogravimetric analysis, derivative thermogravimetry, differential thermal analysis and refractive ind...

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Bibliographic Details
Published in:Research on chemical intermediates 2023-11, Vol.49 (11), p.4879-4895
Main Authors: Rahro, Parissa Naddaf, Shirini, Farhad
Format: Article
Language:English
Subjects:
Catalysis
Chemistry
Chemistry and Materials Science
Condensates
Differential thermal analysis
E coli
Eutectics
Fourier transforms
Infrared analysis
Inorganic Chemistry
Mixtures
Physical Chemistry
Reagents
Refractivity
Synthesis
Thermogravimetric analysis
Thermogravimetry
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Summary:In this work, a novel natural deep eutectic mixture was prepared from glucose, pregabalin and urea and identified using a variety of techniques including Fourier transform infrared spectroscopy, thermogravimetric analysis, derivative thermogravimetry, differential thermal analysis and refractive index measurements. After the characterization the promoting ability of this reagent was studied in the synthesis of 1,8-dioxo-decahydroacridine and hexahydroquinoline derivatives through the one-pot Hantzsch condensation. Easy preparation of the reagent, green process, simple work-up procedure, high yields, and short reaction times are among the most important advantages of the reported protocol. In this research also, the antibacterial activities of the prepared deep eutectic mixture and some of the prepared products were studied against the Bacillus subtilis (Gram-positive) and Escherichia coli (Gram-negative) by the agar well diffusion method.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-023-05125-0