Histological changes in the uterus and implantation status in pregnant mice after oral administration of Maca powder

Maca plant is considered a common herbal plant, known to soothe fetuses in pregnant mice, however there isn’t enough research to know if it’s safe to take during pregnancy. The purpose of this study is to elucidate the role of Activin A hormone, Betacellulin (BTC) growth factor, and Heparin binding...

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Bibliographic Details
Main Authors: Fadhil, Lamyaa Abdulridha, Abbas, Amal Khudair, Al-Dujaily, Saad Salih
Format: Conference Proceeding
Language:English
Subjects:
Binding
Epidermal growth factor
Fetuses
Growth factors
Heparin
Hormones
Implantation
Oral administration
Parameters
Pregnancy
Uterus
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Summary:Maca plant is considered a common herbal plant, known to soothe fetuses in pregnant mice, however there isn’t enough research to know if it’s safe to take during pregnancy. The purpose of this study is to elucidate the role of Activin A hormone, Betacellulin (BTC) growth factor, and Heparin binding epidermal growth factor on embryonic development and pregnancy after oral administration of Maca (Lepidium meyenii) extraction aqueous in aged mice. In line with clinical use, an aqueous extract of Maca was prepared. Pregnant mice were randomly assigned to one of four groups: Two mice groups 8 and 28 weeks old treated with water as a negative control, mice aged 8 weeks old treated with aqueous extract from one of two groups for 10 days, and mice 28 years old treated with aqueous extract for 10 days. The parameters of certain implantation factors such serum progesterone and Activin A hormones, Betacellulin (BTC) growth factor, and Heparin binding epidermal growth factor were assessed. The four groups had substantial differences in parameters. The results clearly show that mice treated with Maca extraction (M group) at ages 8 and 28 weeks had higher mean levels of progesterone hormone and heparin than healthy controls. Also, the results revealed that mice treated with Maca (Lepidium meyenii) extraction (M group) of aged 8 and 28 weeks had greater Betacellulin (BTC) implantation factor and activin A levels than healthy control mice. The implantation factors in young and aged mice were higher by oral administration them an aqueous extract of Maca (Lepidium meyenii).
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0167884