Single-Step Regioselective Oxidative Iodination of Tetrahydrocarbazoles using Periodic Acid in Methanol

Methanol was used as a solvent to perform a one-pot direct oxidation of tetrahydrocarbazoles with periodic acid, followed by regioselective iodination. The oxidative iodination products, substituted 3-iodo-1,2,3,4-tetrahydro-9 H -carbazol-1-ones, were obtained in 60–82% yields. Initial tetrahydrocar...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2023-07, Vol.59 (7), p.1224-1230
Main Authors: Naykode, M. S., Lokhande, M. N., Lokhande, P. D.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Cyclohexanone
Hydrazines
Iodination
Methanol
Organic Chemistry
Oxidation
Regioselectivity
Substitutes
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Summary:Methanol was used as a solvent to perform a one-pot direct oxidation of tetrahydrocarbazoles with periodic acid, followed by regioselective iodination. The oxidative iodination products, substituted 3-iodo-1,2,3,4-tetrahydro-9 H -carbazol-1-ones, were obtained in 60–82% yields. Initial tetrahydrocarbazole derivatives were prepared from cyclohexanone and substituted phenyl hydrazines.
ISSN:1070-4280
1608-3393
DOI:10.1134/S107042802307014X