Overview of in vitro digestion methods to evaluate bioaccessibility of lipophilic compounds in foods

In vitro digestion models for assessing the bioaccessibility of lipophilic compounds from foodstuffs can either be static or dynamic. Carotenoids are the most widely studied compounds, while there is hardly any information on sterols and fat-soluble vitamins available, nor on the use of dynamic meth...

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Bibliographic Details
Published in:Food reviews international 2023-10, Vol.39 (9), p.7126-7147
Main Authors: Faubel, Nerea, Cilla, Antonio, Alegría, Amparo, Barberá, Reyes, Garcia-Llatas, Guadalupe
Format: Article
Language:English
Subjects:
Bioavailability
Carotenoids
Digestion
dynamic system
fat-soluble vitamins
In vitro methods and tests
INFOGEST
Lipophilic
Lipophilicity
static model
Sterols
Vitamins
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Summary:In vitro digestion models for assessing the bioaccessibility of lipophilic compounds from foodstuffs can either be static or dynamic. Carotenoids are the most widely studied compounds, while there is hardly any information on sterols and fat-soluble vitamins available, nor on the use of dynamic methods. There is a large variability in the parameters of static methods, which makes data comparison difficult. To harmonize digestion conditions and compare bioaccessibility, INFOGEST model has been established. This review assesses the most relevant digestion methods (non-INFOGEST, INFOGEST and dynamic) applied to carotenoids, sterols, and fat-soluble vitamins in food matrices in the last ten years.
ISSN:8755-9129
1525-6103
DOI:10.1080/87559129.2022.2143520