Two New Phloroglucinol Derivatives from Syzygium fluviatile

Two new phloroglucinol derivatives were isolated from the leaves of Syzygium fluviatile . The structures were elucidated as (Z,Z,Z)-1-(2,4-dihydroxy-6-methoxyphenyl)-octadeca-9,12,15-trien-1-one ( 1 ) and (Z,Z)-1-(5-methyl-2,4-dihydroxy-6-methoxyphenyl)-octadeca-9,12-dien-1-one ( 2 ) by means of ext...

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Bibliographic Details
Published in:Chemistry of natural compounds 2023-09, Vol.59 (5), p.848-851
Main Authors: Zhang, Ding-Li, Hu, Yi-Kao, He, Yuan-Biao, Zhao, Yong
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Diabetes therapy
Glucosidase
NMR
Nuclear magnetic resonance
Organic Chemistry
Phloroglucinol
Plant Sciences
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Summary:Two new phloroglucinol derivatives were isolated from the leaves of Syzygium fluviatile . The structures were elucidated as (Z,Z,Z)-1-(2,4-dihydroxy-6-methoxyphenyl)-octadeca-9,12,15-trien-1-one ( 1 ) and (Z,Z)-1-(5-methyl-2,4-dihydroxy-6-methoxyphenyl)-octadeca-9,12-dien-1-one ( 2 ) by means of extensive spectroscopic analyses including HR-ESI-MS and NMR spectra. Among them, compound 1 exhibited significant inhibitory activity against α-glucosidase with an IC 50 value of 3.63 μM.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-023-04132-2