Design, fabrication and evaluation of redox/ pH dual‐responsive micelles for tumor targeting delivery and controlled release of paclitaxel

In this study, a polymer with tumor targeting function and dual redox/pH sensitivity is designed and synthesized by integrating chitosan (CS), Poloxamer 407 (P407), cholesterol (CHO), folic acid (FA), and disulfide bonds into one molecule (P407‐CS(FA)‐SS‐CHO). The polymer can self‐assemble in water...

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Bibliographic Details
Published in:Journal of applied polymer science 2023-11, Vol.140 (44)
Main Authors: Xu, Yingxue, Liang, Na, Fu, Jia, Zong, Zhe, Long, Xueling, Sun, Shaoping
Format: Article
Language:English
Subjects:
Biocompatibility
Chemical bonds
Chitosan
Cholesterol
Controlled release
Drug carriers
Folic acid
Glutathione
Materials science
Micelles
Poloxamers
Polymers
Tumors
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Summary:In this study, a polymer with tumor targeting function and dual redox/pH sensitivity is designed and synthesized by integrating chitosan (CS), Poloxamer 407 (P407), cholesterol (CHO), folic acid (FA), and disulfide bonds into one molecule (P407‐CS(FA)‐SS‐CHO). The polymer can self‐assemble in water to form micelles and solubilize paclitaxel (PTX). The mean particle size of PTX‐loaded P407‐CS(FA)‐SS‐CHO micelles is 133 nm. In vitro drug release study demonstrates the acid and glutathione (GSH) triggered PTX release behavior of the micelles. In vitro and in vivo experiments demonstrate the excellent tumor growth inhibition efficacy and low systemic toxicity of the PTX‐loaded micelles. The P407‐CS(FA)‐SS‐CHO micelles will be potential intelligent drug carriers for PTX delivery.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.54614