Strain and process engineering toward continuous industrial fermentation

Most current biotechnology industries are based on batch or fed-batch fermentation processes, which often show low productivity and high production costs compared to chemical processes. To increase the economic competitiveness of biological processes, continuous fermentation technologies are being d...

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Published in:Frontiers of chemical science and engineering 2023-10, Vol.17 (10), p.1336-1353
Main Authors: Dong, Yufei, Zhang, Ye, Liu, Dehua, Chen, Zhen
Format: Article
Language:English
Subjects:
Biological activity
Chemical reactions
Chemistry
Chemistry and Materials Science
Degeneration
Fed batch
Fermentation
Industrial applications
Industrial Chemistry/Chemical Engineering
Installation costs
Microorganisms
Nanotechnology
Product inhibition
Production costs
Productivity
Review Article
Substrate inhibition
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Zhang, Ye
Liu, Dehua
Chen, Zhen
description Most current biotechnology industries are based on batch or fed-batch fermentation processes, which often show low productivity and high production costs compared to chemical processes. To increase the economic competitiveness of biological processes, continuous fermentation technologies are being developed that offer significant advantages in comparison with batch/fed-batch fermentation processes, including: (1) removal of potential substrates and product inhibition, (2) prolonging the microbial exponential growth phase and enhancing productivity, and (3) avoiding repeated fermentation preparation and lowering operation and installation costs. However, several key challenges should be addressed for the industrial application of continuous fermentation processes, including (1) contamination of the fermentation system, (2) degeneration of strains, and (3) relatively low product titer. In this study, we reviewed and discussed metabolic engineering and synthetic biology strategies to address these issues.
doi_str_mv 10.1007/s11705-022-2284-6
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subjects Biological activity
Chemical reactions
Chemistry
Chemistry and Materials Science
Degeneration
Fed batch
Fermentation
Industrial applications
Industrial Chemistry/Chemical Engineering
Installation costs
Microorganisms
Nanotechnology
Product inhibition
Production costs
Productivity
Review Article
Substrate inhibition
title Strain and process engineering toward continuous industrial fermentation
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