Pathogenesis of Post-Traumatic Stress Disorder and Therapeutic Targets

This review summarizes the current literature on the mechanisms of the pathogenesis of a severe stress-induced disorder – post-traumatic stress disorder (PTSD). Hormonal, biochemical, genetic, and morphofunctional changes occurring in PTSD in peripheral organs and in the central nervous system are c...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2023-07, Vol.53 (6), p.1072-1083
Main Authors: Lapshin, M. S., Kondashevskaya, M. V., Epishev, V. V., Patochkina, N. A.
Format: Article
Language:English
Subjects:
Adrenal glands
Anti-inflammatory agents
Anxiety
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Central nervous system
Coronaviruses
Drug delivery
Drug development
Drugs
Functional morphology
Hormones
Inflammation
Neurobiology
Neurosciences
Pathogenesis
Post traumatic stress disorder
Therapeutic targets
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Summary:This review summarizes the current literature on the mechanisms of the pathogenesis of a severe stress-induced disorder – post-traumatic stress disorder (PTSD). Hormonal, biochemical, genetic, and morphofunctional changes occurring in PTSD in peripheral organs and in the central nervous system are characterized. Most researchers are found to have formed the view that chronic inflammation plays a leading role in PTSD. Data from studies of the actions of anti-inflammatory drugs with narrow biochemical targeting are presented. The review concludes with presentation of the hypothesis that the pathogenesis of PTSD should be seen as an integrative inflammatory process of peripheral and central systems. Therapeutic agents in this situation should probably be multifunctional drugs. Judging by the results of the authors’ experimental studies, these are likely to be drugs of the pharmacological heparins group.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-023-01501-w