New benzofuran neolignans with neuroprotective activity from Phyllanthodendron breynioides

A pair of undescribed dihydrobenzofuran neolignan enantiomers, (+/−)-phybrenan A (1a/1b), two new benzofuran neolignans, phybrenan B and C (2 and 3), along with four known neolignans (4 − 7) were obtained from the plants of Phyllanthodendron breynioides P. T. Li. The planar structures of all isolate...

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Published in:Natural product research 2023-11, Vol.37 (22), p.3798-3805
Main Authors: Su, Tong, Pu, Mei-Cen, Tang, Di-Kai, Long, Jin-Chen, Yuan, Fang-Yu, Yin, Ai-Ping, Wu, Shu-Qi, Yin, Sheng, Tang, Gui-Hua
Format: Article
Language:English
Subjects:
Benzofuran
Cell death
Data analysis
Enantiomers
neolignans
Neuroprotection
neuroprotective activity
NMR
Nuclear magnetic resonance
Pheochromocytoma cells
Phyllanthodendron breynioides
Planar structures
Sodium nitroprusside
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cited_by cdi_FETCH-LOGICAL-c418t-6c35814ffd09b6bcc7c1187dd4726c220ec34d15c2801a9e0d1bcd534c1b97753
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container_issue 22
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container_title Natural product research
container_volume 37
creator Su, Tong
Pu, Mei-Cen
Tang, Di-Kai
Long, Jin-Chen
Yuan, Fang-Yu
Yin, Ai-Ping
Wu, Shu-Qi
Yin, Sheng
Tang, Gui-Hua
description A pair of undescribed dihydrobenzofuran neolignan enantiomers, (+/−)-phybrenan A (1a/1b), two new benzofuran neolignans, phybrenan B and C (2 and 3), along with four known neolignans (4 − 7) were obtained from the plants of Phyllanthodendron breynioides P. T. Li. The planar structures of all isolates were demonstrated by the analysis of detailed spectroscopic evidence (NMR, HRMS, and IR), and the absolute configurations of novel neolignans were elucidated by combined calculated and experimental ECD data analysis. The neuroprotective activities of all benzofuran neolignans against sodium nitroprusside (SNP)-induced cell death were examined in rat pheochromocytoma PC12 cells. The results exhibited that three compounds (4 − 6) possessed remarkable neuroprotective activities at 10 µM, better than the positive drug edaravone.
doi_str_mv 10.1080/14786419.2022.2153454
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subjects Benzofuran
Cell death
Data analysis
Enantiomers
neolignans
Neuroprotection
neuroprotective activity
NMR
Nuclear magnetic resonance
Pheochromocytoma cells
Phyllanthodendron breynioides
Planar structures
Sodium nitroprusside
title New benzofuran neolignans with neuroprotective activity from Phyllanthodendron breynioides
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