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EEG Connectivity in ADHD Compared to a Normative Database: A Cohort Analysis of 120 Subjects from the ICAN Study

Introduction/Background. This study explores how EEG connectivity measures in a group of 120 children with ADHD ages 7-10 inclusive differ from an age-matched nonclinical database. We aimed to differentiate connectivity in specific networks, Brodmann area connectivity pairs, and frequencies. Methods...

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Bibliographic Details
Published in:NeuroRegulation 2022-01, Vol.9 (4), p.188-188
Main Authors: Kerson, Cynthia, Lubar, Joel
Format: Article
Language:English
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Summary:Introduction/Background. This study explores how EEG connectivity measures in a group of 120 children with ADHD ages 7-10 inclusive differ from an age-matched nonclinical database. We aimed to differentiate connectivity in specific networks, Brodmann area connectivity pairs, and frequencies. Methods. Subjects were in the International Collaborative ADHD Neurofeedback (ICAN) randomized clinical trial, which explored neurofeedback (NFB) for ADHD. Inclusion criteria were mainly rigorously diagnosed ADHD and an EEG theta/beta power ratio (TBR) of at least 4.5. Pretreatment EEGs records were cleaned for analysis. Using statistical and machine learning algorithms, connectivity values were extracted in coherence, phase, and lag coherence at all Brodmann areas (BA) within the attention dorsal, attention ventral, default mode, executive and salience networks, and many subcortical and cerebellar locations in these same networks in each of the main EEG frequency bands. These values were then compared with a normative database and validated with Monte Carlo simulations. Results. Compared to the normative database, the ADHD children had a higher rate of dysregulation (> ±1.97 SD), in some cases as much as 75%, of the Brodmann pairs observed in coherence and phase between areas 7, 10, and 11 with secondary connections to BAs 21, 30, 35, 37, 39, and 40. BAs 10 and 11 (L and R) are highly represented with dysregulated connections to each other. Conclusion: The three most dysregulated BAs in ADHD are 7, 10, and 11 relevant to ADHD executive-function deficits (prefrontal dysfunction) and provide an important consideration when developing interventions for children with ADHD.
ISSN:2373-0587