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Effects of Saccharina japonica Holdfast Powder on Microbiota in the Caecum of Mice Fed a High-Sucrose and Low-Fibre Diet and in Human Faecal Cultures
The holdfast of Saccharina japonica (SjH) is a by-product of kombu cultivation and is rich in dietary fibres and phenolic compounds. SjH is regarded as a functional food material with anti-infection, immunomodulatory, and anti-viral effects. In this study, we aimed to examine SjH-responsive indigeno...
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| Published in: | Waste and biomass valorization 2023-11, Vol.14 (11), p.3539-3552 |
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| creator | Midorikawa, Yuko Kuda, Takashi Xia, Yumeng Nishizawa, Makoto Yamagishi, Takashi Takahashi, Hajime Lee, Gayang |
| description | The holdfast of
Saccharina japonica
(SjH) is a by-product of kombu cultivation and is rich in dietary fibres and phenolic compounds. SjH is regarded as a functional food material with anti-infection, immunomodulatory, and anti-viral effects. In this study, we aimed to examine SjH-responsive indigenous gut bacteria (SjH-RIB) in Institute of Cancer Research (ICR) mice fed a diet containing either no fibre or 5% (w w
−1
) SjH for 14 days. Additionally, we sought to determine the effects of SjH on organic acids, putrefactive compounds, and microbiota in human faecal cultures. Human stool samples collected from five healthy volunteers were incubated without (control) or with 2% (w w
−1
) SjH at 37 °C for 24 h. The microbiota in murine caecal samples and human faecal cultures were analysed via 16S rRNA (V4) amplicon sequencing. Compared to the mice fed no-fibre diets, mice fed SjH showed high caecal levels of
Clostridium
sensu stricto 1
-,
Oscillospiraceae spp.-,
Parabacteroides
spp.-, and
Alistipes
spp.-like bacteria. In contrast,
Allobaculum
, a dominant genus in the no-fibre group, was not detected in the SjH group. In human faecal cultures, the levels of acetate and propionate were higher in SjH-cultures than in the control cultures (
p
|
| doi_str_mv | 10.1007/s12649-023-02064-0 |
| format | article |
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Saccharina japonica
(SjH) is a by-product of kombu cultivation and is rich in dietary fibres and phenolic compounds. SjH is regarded as a functional food material with anti-infection, immunomodulatory, and anti-viral effects. In this study, we aimed to examine SjH-responsive indigenous gut bacteria (SjH-RIB) in Institute of Cancer Research (ICR) mice fed a diet containing either no fibre or 5% (w w
−1
) SjH for 14 days. Additionally, we sought to determine the effects of SjH on organic acids, putrefactive compounds, and microbiota in human faecal cultures. Human stool samples collected from five healthy volunteers were incubated without (control) or with 2% (w w
−1
) SjH at 37 °C for 24 h. The microbiota in murine caecal samples and human faecal cultures were analysed via 16S rRNA (V4) amplicon sequencing. Compared to the mice fed no-fibre diets, mice fed SjH showed high caecal levels of
Clostridium
sensu stricto 1
-,
Oscillospiraceae spp.-,
Parabacteroides
spp.-, and
Alistipes
spp.-like bacteria. In contrast,
Allobaculum
, a dominant genus in the no-fibre group, was not detected in the SjH group. In human faecal cultures, the levels of acetate and propionate were higher in SjH-cultures than in the control cultures (
p
< 0.05). Furthermore, SjH-cultures showed low phenol contents. The genera
Bacteroides
,
Faecalibacterium
, and
Bifidobacterium
were more abundant in SjH-cultures than in the control cultures, although the abundance of each amplicon sequence variant in the SjH-RIB genera varied among individuals. These results suggest that the functions of SjH might be correlated with altered gut microbiota composition.
Graphical Abstract</description><identifier>ISSN: 1877-2641</identifier><identifier>EISSN: 1877-265X</identifier><identifier>DOI: 10.1007/s12649-023-02064-0</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acetic acid ; Antiviral agents ; Bacteria ; Culture ; Diet ; Dietary fiber ; Engineering ; Environment ; Environmental Engineering/Biotechnology ; Feces ; Fibers ; Functional foods & nutraceuticals ; Immunomodulation ; Industrial Pollution Prevention ; Intestinal microflora ; Microbiota ; Microorganisms ; Nutrient deficiency ; Organic acids ; Original Paper ; Phenolic compounds ; Phenols ; Renewable and Green Energy ; rRNA 16S ; Saccharina japonica ; Sucrose ; Waste Management/Waste Technology</subject><ispartof>Waste and biomass valorization, 2023-11, Vol.14 (11), p.3539-3552</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-5a8ba29afe8d813e27e692585f79545a8127cfc029f31e7968a0cac5fd5ea6b13</citedby><cites>FETCH-LOGICAL-c319t-5a8ba29afe8d813e27e692585f79545a8127cfc029f31e7968a0cac5fd5ea6b13</cites><orcidid>0000-0003-1300-808X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Midorikawa, Yuko</creatorcontrib><creatorcontrib>Kuda, Takashi</creatorcontrib><creatorcontrib>Xia, Yumeng</creatorcontrib><creatorcontrib>Nishizawa, Makoto</creatorcontrib><creatorcontrib>Yamagishi, Takashi</creatorcontrib><creatorcontrib>Takahashi, Hajime</creatorcontrib><creatorcontrib>Lee, Gayang</creatorcontrib><title>Effects of Saccharina japonica Holdfast Powder on Microbiota in the Caecum of Mice Fed a High-Sucrose and Low-Fibre Diet and in Human Faecal Cultures</title><title>Waste and biomass valorization</title><addtitle>Waste Biomass Valor</addtitle><description>The holdfast of
Saccharina japonica
(SjH) is a by-product of kombu cultivation and is rich in dietary fibres and phenolic compounds. SjH is regarded as a functional food material with anti-infection, immunomodulatory, and anti-viral effects. In this study, we aimed to examine SjH-responsive indigenous gut bacteria (SjH-RIB) in Institute of Cancer Research (ICR) mice fed a diet containing either no fibre or 5% (w w
−1
) SjH for 14 days. Additionally, we sought to determine the effects of SjH on organic acids, putrefactive compounds, and microbiota in human faecal cultures. Human stool samples collected from five healthy volunteers were incubated without (control) or with 2% (w w
−1
) SjH at 37 °C for 24 h. The microbiota in murine caecal samples and human faecal cultures were analysed via 16S rRNA (V4) amplicon sequencing. Compared to the mice fed no-fibre diets, mice fed SjH showed high caecal levels of
Clostridium
sensu stricto 1
-,
Oscillospiraceae spp.-,
Parabacteroides
spp.-, and
Alistipes
spp.-like bacteria. In contrast,
Allobaculum
, a dominant genus in the no-fibre group, was not detected in the SjH group. In human faecal cultures, the levels of acetate and propionate were higher in SjH-cultures than in the control cultures (
p
< 0.05). Furthermore, SjH-cultures showed low phenol contents. The genera
Bacteroides
,
Faecalibacterium
, and
Bifidobacterium
were more abundant in SjH-cultures than in the control cultures, although the abundance of each amplicon sequence variant in the SjH-RIB genera varied among individuals. These results suggest that the functions of SjH might be correlated with altered gut microbiota composition.
Graphical Abstract</description><subject>Acetic acid</subject><subject>Antiviral agents</subject><subject>Bacteria</subject><subject>Culture</subject><subject>Diet</subject><subject>Dietary fiber</subject><subject>Engineering</subject><subject>Environment</subject><subject>Environmental Engineering/Biotechnology</subject><subject>Feces</subject><subject>Fibers</subject><subject>Functional foods & nutraceuticals</subject><subject>Immunomodulation</subject><subject>Industrial Pollution Prevention</subject><subject>Intestinal microflora</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Nutrient deficiency</subject><subject>Organic acids</subject><subject>Original Paper</subject><subject>Phenolic compounds</subject><subject>Phenols</subject><subject>Renewable and Green Energy</subject><subject>rRNA 16S</subject><subject>Saccharina japonica</subject><subject>Sucrose</subject><subject>Waste Management/Waste Technology</subject><issn>1877-2641</issn><issn>1877-265X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kUFLAzEQhRdRsKh_wNOA59Uk291NjlKtFSoKKngL0-ykTWk3NdlF_CH-X9NW9OYhJMx73xvCy7Jzzi45Y_VV5KIaqpyJIh1WDXN2kA24rOtcVOXb4e97yI-zsxiXjDHBuRRFPci-bq0l00XwFp7RmAUG1yIsceNbZxAmftVYjB08-Y-GAvgWHpwJfuZ8h-Ba6BYEIyTTr7cRSSMYUwOJdPNF_twnbyTAtoGp_8jHbhYIbhx1u1HiJ_0aWxinBFzBqF91faB4mh1ZXEU6-7lPstfx7ctokk8f7-5H19PcFFx1eYlyhkKhJdlIXpCoqVKilKWtVTlMKhe1sYYJZQtOtaokMoOmtE1JWM14cZJd7HM3wb_3FDu99H1o00otpBRSMSlUcom9a_uXGMjqTXBrDJ-aM71tQO8b0KkBvWtAswQVeygmczun8Bf9D_UNBCCIww</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Midorikawa, Yuko</creator><creator>Kuda, Takashi</creator><creator>Xia, Yumeng</creator><creator>Nishizawa, Makoto</creator><creator>Yamagishi, Takashi</creator><creator>Takahashi, Hajime</creator><creator>Lee, Gayang</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-1300-808X</orcidid></search><sort><creationdate>20231101</creationdate><title>Effects of Saccharina japonica Holdfast Powder on Microbiota in the Caecum of Mice Fed a High-Sucrose and Low-Fibre Diet and in Human Faecal Cultures</title><author>Midorikawa, Yuko ; Kuda, Takashi ; Xia, Yumeng ; Nishizawa, Makoto ; Yamagishi, Takashi ; Takahashi, Hajime ; Lee, Gayang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-5a8ba29afe8d813e27e692585f79545a8127cfc029f31e7968a0cac5fd5ea6b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acetic acid</topic><topic>Antiviral agents</topic><topic>Bacteria</topic><topic>Culture</topic><topic>Diet</topic><topic>Dietary fiber</topic><topic>Engineering</topic><topic>Environment</topic><topic>Environmental Engineering/Biotechnology</topic><topic>Feces</topic><topic>Fibers</topic><topic>Functional foods & nutraceuticals</topic><topic>Immunomodulation</topic><topic>Industrial Pollution Prevention</topic><topic>Intestinal microflora</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Nutrient deficiency</topic><topic>Organic acids</topic><topic>Original Paper</topic><topic>Phenolic compounds</topic><topic>Phenols</topic><topic>Renewable and Green Energy</topic><topic>rRNA 16S</topic><topic>Saccharina japonica</topic><topic>Sucrose</topic><topic>Waste Management/Waste Technology</topic><toplevel>online_resources</toplevel><creatorcontrib>Midorikawa, Yuko</creatorcontrib><creatorcontrib>Kuda, Takashi</creatorcontrib><creatorcontrib>Xia, Yumeng</creatorcontrib><creatorcontrib>Nishizawa, Makoto</creatorcontrib><creatorcontrib>Yamagishi, Takashi</creatorcontrib><creatorcontrib>Takahashi, Hajime</creatorcontrib><creatorcontrib>Lee, Gayang</creatorcontrib><collection>CrossRef</collection><jtitle>Waste and biomass valorization</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Midorikawa, Yuko</au><au>Kuda, Takashi</au><au>Xia, Yumeng</au><au>Nishizawa, Makoto</au><au>Yamagishi, Takashi</au><au>Takahashi, Hajime</au><au>Lee, Gayang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Saccharina japonica Holdfast Powder on Microbiota in the Caecum of Mice Fed a High-Sucrose and Low-Fibre Diet and in Human Faecal Cultures</atitle><jtitle>Waste and biomass valorization</jtitle><stitle>Waste Biomass Valor</stitle><date>2023-11-01</date><risdate>2023</risdate><volume>14</volume><issue>11</issue><spage>3539</spage><epage>3552</epage><pages>3539-3552</pages><issn>1877-2641</issn><eissn>1877-265X</eissn><abstract>The holdfast of
Saccharina japonica
(SjH) is a by-product of kombu cultivation and is rich in dietary fibres and phenolic compounds. SjH is regarded as a functional food material with anti-infection, immunomodulatory, and anti-viral effects. In this study, we aimed to examine SjH-responsive indigenous gut bacteria (SjH-RIB) in Institute of Cancer Research (ICR) mice fed a diet containing either no fibre or 5% (w w
−1
) SjH for 14 days. Additionally, we sought to determine the effects of SjH on organic acids, putrefactive compounds, and microbiota in human faecal cultures. Human stool samples collected from five healthy volunteers were incubated without (control) or with 2% (w w
−1
) SjH at 37 °C for 24 h. The microbiota in murine caecal samples and human faecal cultures were analysed via 16S rRNA (V4) amplicon sequencing. Compared to the mice fed no-fibre diets, mice fed SjH showed high caecal levels of
Clostridium
sensu stricto 1
-,
Oscillospiraceae spp.-,
Parabacteroides
spp.-, and
Alistipes
spp.-like bacteria. In contrast,
Allobaculum
, a dominant genus in the no-fibre group, was not detected in the SjH group. In human faecal cultures, the levels of acetate and propionate were higher in SjH-cultures than in the control cultures (
p
< 0.05). Furthermore, SjH-cultures showed low phenol contents. The genera
Bacteroides
,
Faecalibacterium
, and
Bifidobacterium
were more abundant in SjH-cultures than in the control cultures, although the abundance of each amplicon sequence variant in the SjH-RIB genera varied among individuals. These results suggest that the functions of SjH might be correlated with altered gut microbiota composition.
Graphical Abstract</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s12649-023-02064-0</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-1300-808X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1877-2641 |
| ispartof | Waste and biomass valorization, 2023-11, Vol.14 (11), p.3539-3552 |
| issn | 1877-2641 1877-265X |
| language | eng |
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| source | Springer Link |
| subjects | Acetic acid Antiviral agents Bacteria Culture Diet Dietary fiber Engineering Environment Environmental Engineering/Biotechnology Feces Fibers Functional foods & nutraceuticals Immunomodulation Industrial Pollution Prevention Intestinal microflora Microbiota Microorganisms Nutrient deficiency Organic acids Original Paper Phenolic compounds Phenols Renewable and Green Energy rRNA 16S Saccharina japonica Sucrose Waste Management/Waste Technology |
| title | Effects of Saccharina japonica Holdfast Powder on Microbiota in the Caecum of Mice Fed a High-Sucrose and Low-Fibre Diet and in Human Faecal Cultures |
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