Cocrystal formation by anti-solvent slurry

An anti-solvent slurry method for cocrystal formation is developed and tested in 25 carbamazepine cocrystal systems. With a low solvent/anti-solvent volume ratio, it reduces solubility of reactants and products, and levels out solubility difference of reactants, and consequently generates cocrystals...

Full description

Saved in:
Bibliographic Details
Published in:CrystEngComm 2023-10, Vol.25 (42), p.5882-5886
Main Authors: Li, Yi, Li, Shun-Yu, Dai, Xia-Lin, Lu, Tong-Bu, Chen, Jia-Mei
Format: Article
Language:English
Subjects:
Slurries
Solubility
Solvents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An anti-solvent slurry method for cocrystal formation is developed and tested in 25 carbamazepine cocrystal systems. With a low solvent/anti-solvent volume ratio, it reduces solubility of reactants and products, and levels out solubility difference of reactants, and consequently generates cocrystals with a higher success rate, higher purity and higher yield than commonly used slurry methods. An anti-solvent slurry method for cocrystal formation is developed and tested in 25 carbamazepine cocrystal systems, which reveals that it is a facile, efficient and reliable method for cocrystal discovery and synthesis.
ISSN:1466-8033
1466-8033
DOI:10.1039/d3ce00486d