Water‐soluble hyperbranched polymer with high curcumin content

Curcumin is one of the promising anticancer drugs but has the problems of poor water solubility and rapid degradation in aqueous solution. In this study, a hyperbranched curcumin polymer having many carboxylic end groups is synthesized. The polymer is highly water‐soluble and contains a high amount...

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Bibliographic Details
Published in:Journal of applied polymer science 2023-12, Vol.140 (46)
Main Authors: Nakayama, Yusuke, Ito, Yutaro, Fukaminato, Tsuyoshi, Xu, Wei, Niidome, Takuro, Kurihara, Seiji, Kim, Sunnam
Format: Article
Language:English
Subjects:
Aqueous solutions
Degradation
Materials science
Polymers
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Summary:Curcumin is one of the promising anticancer drugs but has the problems of poor water solubility and rapid degradation in aqueous solution. In this study, a hyperbranched curcumin polymer having many carboxylic end groups is synthesized. The polymer is highly water‐soluble and contains a high amount of curcumins. Remarkable improvement of stability toward degradation and aggregation in aqueous solution is achieved. Its cellular uptake and cytotoxicity are also confirmed.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.54673