Exploitation of multi-walled carbon nanotubes/Cu()-metal organic framework based glassy carbon electrode for the determination of orphenadrine citrate

• Published in: RSC advances 2023-10, Vol.13 (44), p.3117-3126
• Main Authors: Kammoun, Ahmed K, Abdelrahman, Mona H, Khayyat, Ahdab N, Elbaramawi, Samar S, Ibrahim, Tarek S, Abdallah, Nehad A
• Format: Article
• Language: English
• Subjects: Blood plasma; Carbon; Cerebrospinal fluid; Chemistry; Comparative studies; Copper; Cyclodextrins; Electrochemistry; Electrodes; Glassy carbon; Ion exchangers; Linearity; Metal-organic frameworks; Multi wall carbon nanotubes; Quality control; Sensors; Transducers
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/d3ra06710f

Metal organic frameworks (MOFs), with structural tunability, high metal content and large surface area have recently attracted the attention of researchers in the field of electrochemistry. In this work, an unprecedented use of multi-walled carbon nanotubes (MWCNTs)/copper-based metal-organic framework (Cu-BTC MOF) composite as an ion-to-electron transducer in a potentiometric sensor is proposed for the determination of orphenadrine citrate. A comparative study was conducted between three proposed glassy carbon electrodes, Cu-MOF, (MWCNTs) and MWCNTs/Cu-MOF composite based sensors, where Cu-MOF, MWCNTs and their composite were utilized as the ion-to-electron transducers. The sensors were developed for accurate and precise determination of orphenadrine citrate in pharmaceutical dosage form, spiked real human plasma and artificial cerebrospinal fluid (ACSF). The sensors employed β-cyclodextrin as a recognition element with the aid of potassium tetrakis(4-chlorophenyl)borate (KTpCIPB) as a lipophilic ion exchanger. The sensors that were assessed based on the guidelines recommended by IUPAC and demonstrated a linear response within the concentration range of 10 −7 M to 10 −3 M, 10 −6 M to 10 −2 M and 10 −8 M to 10 −2 M for Cu-MOF, MWCNTs and MWCNTs/Cu-MOF composite based sensors, respectively. MWCNTs/Cu-MOF composite based sensor showed superior performance over other sensors regarding lower limit of detection (LOD), wider linearity range and faster response. The sensors demonstrated their potential as effective options for the analysis of orphenadrine citrate in quality control laboratories and in different healthcare activities. Three potentiometric GCEs were applied for the determination of orphenadrine citrate with the utilization of MWCNTs, Cu-BTC MOF and MWCNTs/CU-MOF composite separately as ion-to-electron transducers and β-cyclodextrin as a recognition element.