Quercetin: an effective polyphenol in alleviating diabetes and diabetic complications

Various studies, especially in recent years, have shown that quercetin has beneficial therapeutic effects in various human diseases, including diabetes. Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity. Quercetin appears to...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2023, Vol.ahead-of-print (ahead-of-print), p.1-24
Main Authors: Yan, Lei, Vaghari-Tabari, Mostafa, Malakoti, Faezeh, Moein, Soheila, Qujeq, Durdi, Yousefi, Bahman, Asemi, Zatollah
Format: Article
Language:English
Subjects:
AKT protein
Antidiabetics
Clinical trials
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetic neuropathy
Inflammation
Insulin
Insulin resistance
Nephropathy
NF-κB protein
Oxidants
Oxidizing agents
Pathogenesis
Quercetin
Retinopathy
Reviews
Wound healing
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Summary:Various studies, especially in recent years, have shown that quercetin has beneficial therapeutic effects in various human diseases, including diabetes. Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity. Quercetin appears to affect many factors and signaling pathways involved in insulin resistance and the pathogenesis of type 2 of diabetes. TNFα, NFKB, AMPK, AKT, and NRF2 are among the factors that are affected by quercetin. In addition, quercetin can be effective in preventing and ameliorating the diabetic complications, including diabetic nephropathy, cardiovascular complications, neuropathy, delayed wound healing, and retinopathy, and affects the key mechanisms involved in the pathogenesis of these complications. These positive effects of quercetin may be related to its anti-inflammatory and anti-oxidant properties. In this article, after a brief review of the pathogenesis of insulin resistance and type 2 diabetes, we will review the latest findings on the anti-diabetic effects of quercetin with a molecular perspective. Then we will review the effects of quercetin on the key mechanisms of pathogenesis of diabetes complications including nephropathy, cardiovascular complications, neuropathy, delayed wound healing, and retinopathy. Finally, clinical trials investigating the effect of quercetin on diabetes and diabetes complications will be reviewed.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2022.2067825