Detection and molecular characterisation of canine adenovirus type 1 from a fatal case of infectious canine hepatitis from India

Canine adenovirus (CAdV), a non‐enveloped, linear dsDNA virus, is a member of the genus Mastadenovirus of the family Adenoviridae. Two different serotypes of CAdVs, canine adenovirus type 1 (CAdV‐1), which causes infectious canine hepatitis (ICH), and canine adenovirus type 2 (CAdV‐2), which causes...

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Bibliographic Details
Published in:Veterinary record case reports 2023-12, Vol.11 (4)
Main Authors: Syamily, Shaji, Rajasekhar, R, Anoopraj, R, Ravishankar, Chintu, Jishnu, Haridas Piriyath
Format: Article
Language:English
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Summary:Canine adenovirus (CAdV), a non‐enveloped, linear dsDNA virus, is a member of the genus Mastadenovirus of the family Adenoviridae. Two different serotypes of CAdVs, canine adenovirus type 1 (CAdV‐1), which causes infectious canine hepatitis (ICH), and canine adenovirus type 2 (CAdV‐2), which causes canine infectious laryngotracheitis, have been identified in dogs. In this report, we discuss a case of fatal CAdV‐1 infection in a 4‐month‐old, male, unvaccinated, Rajapalayam breed dog. Postmortem examination results were suggestive of CAdV‐1 infection, which was confirmed by histopathological examination, molecular characterisation and phylogenetic analysis. Sequence analysis of the CAdV‐1 strain showed a close similarity with the Australasian‐Europe cluster, a high identity (99.78% nucleotide and 98.91% amino acid identities) with a CAdV‐1 isolate (KU75571) from a fox in the United Kingdom, and a unique substitution (W126S) in the E3 protein encoding sequence.
ISSN:2052-6121
2052-6121
DOI:10.1002/vrc2.698