Comparative Estimation of C-terminal Cross-linked Telopeptide of Type I Collagen Levels in Gingival Crevicular Fluid in Diabetic and Nondiabetic Patients with Chronic Periodontitis: A Prospective Clinical Study

Aim: To estimate C-terminal cross-linked telopeptide (CTx) levels in GCF, using ELISA in diabetic and nondiabetic patients with chronic periodontitis. Materials and Methods: A total of 42 patients were recruited: 21 type II diabetic patients with chronic periodontitis (group A) and 21 nondiabetic pa...

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Published in:Journal of international oral health 2023-09, Vol.15 (5), p.463-468
Main Authors: Ningombam, Anushree, Dhalla, Nipun, Palwankar, Pooja, Goyal, Anjana, Pandey, Ruchi
Format: Article
Language:English
Subjects:
Biomarkers
Chronic illnesses
Chronic infection
Clinical outcomes
Collagen
Collagen (type I)
Complications and side effects
Diabetes
Diabetes mellitus
Diagnosis
Enzyme-linked immunosorbent assay
Evaluation
Gum disease
Health aspects
Peptides
Periodontitis
Type 2 diabetes
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Summary:Aim: To estimate C-terminal cross-linked telopeptide (CTx) levels in GCF, using ELISA in diabetic and nondiabetic patients with chronic periodontitis. Materials and Methods: A total of 42 patients were recruited: 21 type II diabetic patients with chronic periodontitis (group A) and 21 nondiabetic patients with chronic periodontitis (group B). Scaling and root planing (SRP) were done in groups, followed by collection of GCF samples and recording of clinical variables. Measurements for clinical indicators of periodontal health were taken on 0 day (baseline), first and after third month. The Ctx level of GCF was taken at baseline and after 3 months using enzyme-linked immunosorbent assay (ELISA). GPower software (version 3.0) was used. Paired t tests and Student’s t tests as well as parametric tests were used to analyze the results. The threshold for significance was fixed at P < 0.05. Result: Following SRP, there was a significant reduction in Ctx levelsand an improvement in clinical parameters in both groups. There is a negative correlation uniting CTx quantity with an improvement in periodontal conditions in both diabetic and nondiabetic patients. Conclusion: CTx levels in both diabetic and nondiabetic candidates with chronic periodontitis infection were reduced after nonsurgical periodontal therapy.
ISSN:0976-7428
0976-1799
DOI:10.4103/jioh.jioh_135_23