Origanum majorana Essential Oil Ameliorated the Behavioral, Biochemical, Physiological and Performance Perturbations Induced by Aflatoxin B1 in Growing Rabbits

• Published in: Annals of animal science 2023-11, Vol.23 (4), p.1201-1210
• Main Authors: Farag, Mayada R., Gharib, Heba S.A., El-Naggar, Karima, Hendam, Basma M., Ahmad, Enas A.M., Alagawany, Mahmoud, El-Ghazali, Hanaa M.
• Format: Article
• Language: English
• Subjects: Aflatoxin B1; Aflatoxins; antioxidant; Antioxidants; behavior; Bioaccumulation; Biomarkers; Diet; DNA damage; Enzymes; Essential oils; Exposure; growth; Heat shock factors; Heat shock proteins; Inflammation; Inflammatory response; Lipids; Liver; marjoram; Oils & fats; Oxidative stress; Perturbation; Proteins; rabbit; Rabbits; Residues; Toxicity; Tumor suppressor genes; γ-Interferon
• ISSN: 2300-8733; 1642-3402; 2300-8733
• DOI: 10.2478/aoas-2023-0035

The current study assessed the benefits of marjoram essential oil (MEO) in reducing the aflatoxin B1 (AFB1) toxicity in growing rabbits. Forty-eight rabbits, aged 4 weeks, were randomly assigned to four groups (4 replications of 3 rabbits/replicate) as follows: BD group (control); AFB1 group (supplemented with AFB1 0.3 mg/kg diet); MEO-supplemented group (1 g MEO/kg diet); AFB1 + MEO group (AFB1 0.3 mg/kg diet + 1 g MEO/kg diet). AFB1 exposure resulted in reduction of rabbit growth and total protein and albumin content in serum; increased liver function related enzymes (ALP, ALT and AST); induced oxidative stress displayed by lower level of antioxidant enzymes (CAT and GSH), increased biomarkers of DNA and lipid oxidative damage with significant upregulation of the tumor suppressor protein interferon-γ, interleukin 1β, tumor necrosis factor-α and heat shock protein-70 when compared to the control (P