Synthesis, Crystal Structure, and Biological Activity of α-Hydroxyphosphonates

A series of dialkyl [aryl(hydroxy)methyl]phosphonates with various substituents at the phosphorus atom was obtained by the Abramov reaction. The structure of the isolated products was confirmed by IR and NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. All the obtained compounds...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2023-08, Vol.59 (8), p.1342-1347
Main Authors: Sedov, A. N., Davletshin, R. R., Davletshina, N. V., Ivshin, K. A., Fedonin, A. P., Osogostok, A. R., Shulaeva, M. P.
Format: Article
Language:English
Subjects:
Biological activity
Chemistry
Chemistry and Materials Science
Crystal structure
Infrared spectroscopy
Mass spectrometry
NMR spectroscopy
Organic Chemistry
Phosphonates
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Summary:A series of dialkyl [aryl(hydroxy)methyl]phosphonates with various substituents at the phosphorus atom was obtained by the Abramov reaction. The structure of the isolated products was confirmed by IR and NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. All the obtained compounds demonstrated activity against B. cereus and S. aureus bacterial strains.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428023080080