Synthesis and Hemostatic Activity of Substituted Potassium 1-Cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates

Ring opening in 2-[(2-oxofuran-3(2 H )-yliden)amino]-4,5,6,7-tetrahydrobenzo[ b ]thiophene-3-carbonitriles under the action of various nitriles and t -BuOK was used to synthesize previously unknown substituted potassium 1-cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo[ b ]thiophen-2-yl)amino}-5-oxopenta-...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2023-08, Vol.59 (8), p.1322-1328
Main Authors: Lipin, D. V., Kozlov, D. A., Shadrin, V. M., Parkoma, K. Yu, Starkov, A. V., Shipilovskikh, D. A., Pulina, N. A., Shipilovskikh, S. A.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Nitriles
NMR spectroscopy
Organic Chemistry
Potassium
Ring opening
Substitutes
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Summary:Ring opening in 2-[(2-oxofuran-3(2 H )-yliden)amino]-4,5,6,7-tetrahydrobenzo[ b ]thiophene-3-carbonitriles under the action of various nitriles and t -BuOK was used to synthesize previously unknown substituted potassium 1-cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo[ b ]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates. The structure of the obtained compounds was confirmed by 1 H and 13 C NMR spectroscopy and elemental analysis. The anticoagulant activity of the products was studied.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428023080055