Extracellular vesicles in bone homeostasis: key roles of physiological and pathological conditions

Extracellular vesicles (EVs) are small particles with lipid bilayer membranes that are secreted by all cell types and are widely known as crucial intercellular communication mediators, shuttling biologically active molecules. The bone is a typically preferred site of cancer metastasis due to its uni...

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Bibliographic Details
Published in:Journal of bone and mineral metabolism 2023-05, Vol.41 (3), p.345-357
Main Authors: Tamura, Takaaki, Yoshioka, Yusuke, Sakamoto, Shinichi, Ichikawa, Tomohiko, Ochiya, Takahiro
Format: Article
Language:English
Subjects:
Biological activity
Biosynthesis
Bone cancer
Bone growth
Bone marrow
Bone tumors
Bone turnover
Cancer
Cell interactions
Cells
Communication
Extracellular vesicles
Homeostasis
Invited Review
Lipid bilayers
Medical prognosis
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Metastases
Metastasis
MicroRNAs
Orthopedics
Physiology
Tumor microenvironment
Tumor necrosis factor-TNF
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Summary:Extracellular vesicles (EVs) are small particles with lipid bilayer membranes that are secreted by all cell types and are widely known as crucial intercellular communication mediators, shuttling biologically active molecules. The bone is a typically preferred site of cancer metastasis due to its unique cellular compositions and dynamics. Bone cell-derived EVs serve as regulators that orchestrate harmonious bone homeostasis. Cancer cells secrete specific EVs in a series of the bone metastatic process to dominate the bone microenvironment. Additionally, cancer cell-related EVs contribute to pre-metastatic niche formation, bone homeostasis disruption, and tumor bone progression and survival. Here, we investigated recent studies on EV-mediated crosstalk in the bone tumor microenvironment. Furthermore, this review aimed to elucidate the EV-based therapeutic perspectives for bone metastasis.
ISSN:0914-8779
1435-5604
DOI:10.1007/s00774-022-01362-2