Preclinical assessment of chitosan–polyvinyl alcohol–graphene oxide nanocomposite scaffolds as a wound dressing

The present research aimed to examine the biological properties of chitosan (CS)–polyvinyl alcohol (PVA) scaffolds reinforced with graphene oxide (GO) nanosheets, as wound dressings. The scaffolds were characterized by various techniques. The scanning electron microscopy (SEM) and thermogravimetry a...

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Bibliographic Details
Published in:Polymers & polymer composites 2021-11, Vol.29 (9_suppl), p.S926-S936
Main Authors: Montazeri, Arash, Saeedi, Fariba, Bahari, Yaser, Ahmadi Daryakenari, Ahmad
Format: Article
Language:English
Subjects:
Biocompatibility
Biological properties
Biomedical materials
Cell culture
Chitosan
Contact angle
Fibroblasts
Graphene
In vivo methods and tests
Investigations
Mechanical properties
Molecular weight
Morphology
Nanocomposites
Polymers
Polyvinyl alcohol
Scaffolds
Spectrum analysis
Thermal analysis
Thermogravimetry
Tissue engineering
Toxicity
Viscoelasticity
Wound healing
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Summary:The present research aimed to examine the biological properties of chitosan (CS)–polyvinyl alcohol (PVA) scaffolds reinforced with graphene oxide (GO) nanosheets, as wound dressings. The scaffolds were characterized by various techniques. The scanning electron microscopy (SEM) and thermogravimetry analyses (TGAs) were used to investigate distribution of the GO within the polymer. The viscoelastic properties were evaluated by dynamic mechanical thermal analysis (DMTA) to examine the quality of a wound dressing. In vitro and in vivo studies were conducted to assess the biocompatibility of the scaffolds as wound dressing. The cell viability and proliferation results indicated that mouse fibroblast cells (L929) could adhere on the 50CS–50PVA/3 wt% GO scaffold. Herewith, the fabricated CS–PVA–GO nanocomposite scaffolds are suggested as promising biomaterials for skin tissue engineering and wound dressing.
ISSN:0967-3911
1478-2391
DOI:10.1177/09673911211029242