Two New Antifungal Indole Alkaloids from an Endophytic Fungi Aspergillus felis Obtained from Cigar Tobacco

With the aim of screening more bioactivity metabolites, in this study, two new indole alkaloids, felisindoles A and B ( 1 and 2 ), were isolated from the cigar tobacco-derived endophytic fungi Aspergillus felis . Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spec...

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Published in:Chemistry of natural compounds 2023-11, Vol.59 (6), p.1132-1136
Main Authors: Kong, Ling-Wang, Qiu, Wan-Ya, Chen, Meng-Si, Yang, Wan-Long, Shen, Jun-Ru, Tang, Xu-Bing, He, Xiao-Hui, Li, Yin-Ke, Hu, Qiu-Fen, Kong, Guang-Hui
Format: Article
Language:English
Subjects:
Alkaloids
Antifungal agents
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Comparative analysis
Fungi
Fungicides
Metabolites
NMR
Nuclear magnetic resonance
Organic Chemistry
Plant Sciences
Tobacco
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Summary:With the aim of screening more bioactivity metabolites, in this study, two new indole alkaloids, felisindoles A and B ( 1 and 2 ), were isolated from the cigar tobacco-derived endophytic fungi Aspergillus felis . Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic data. Interestingly, the anti-fungi activity assay revealed that compounds 1 and 2 showed potential anti- G . cichoracearum (the main pathogen of tobacco powdery mildew disease) activity with inhibition rates of 72.6% ± 5.2, and 61.7% ± 5.0, respectively, compared to the negative control. However, these rates are lower than that of the positive control (with an inhibition rate of 93.2% ± 5.5).
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-023-04210-5