Recent Advancements and Patent Search on Polymeric Nanoparticles

Nanosized particles have enticing properties that have received significant attention in recent decades. Polymeric nanoparticles (PNs) are particulates ranging from 1 to 1000 nm that can be loaded with active chemicals that are either entrapped within or surface-adsorbed onto the polymeric core. The...

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Bibliographic Details
Published in:BioNanoScience 2023-12, Vol.13 (4), p.1463-1469
Main Authors: Patnaik, Aiswarya, Jena, Goutam Kumar, Patra, Ch. Niranjan
Format: Article
Language:English
Subjects:
Anticancer properties
Antitumor agents
Biological and Medical Physics
Biomaterials
Biophysics
Cancer
Circuits and Systems
Disorders
Drug delivery
Engineering
Eye diseases
Eye disorders
Literature reviews
Nanoparticles
Nanospheres
Nanotechnology
Particulates
Patent searches
Pharmacokinetics
Reviews
Side effects
Tumor cells
Citations: Items that this one cites
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Summary:Nanosized particles have enticing properties that have received significant attention in recent decades. Polymeric nanoparticles (PNs) are particulates ranging from 1 to 1000 nm that can be loaded with active chemicals that are either entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” refers to both nanocapsules and nanospheres, which differ in morphological aspect. Polymeric nanoparticles have shown technological breakthroughs in the detection and management of many diseases. This review provides an overview of polymers used in PNs for the treatment of cancer and ocular diseases. PNs used for the treatment of different types of cancer and ocular disorders are listed with recent patents. This review also focuses on technological advancements with special reference to the safe-by-design concept. From the literature survey, it was observed that PNs can be used as nanocarriers for the effective delivery of nanomedicines to cancer cells and improve ocular drug delivery. PNs act by increasing solubility, controlling pharmacokinetics, extending release, reducing side effects, and achieving a therapeutic effect with a reduced dose. PNs have shown promising potential in targeting anticancer agents to specific tumor cells by active targeting. This review touches on important considerations, advancements, and challenges of PNs for the treatment of cancer and ocular disorders.
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-023-01220-z