Antibody Libraries as Platforms to Exploring Target and Receptor Pleiotropy

Monoclonal antibodies (mAbs) have become important classes in biopharmaceutical products. The selection of antibodies has traditionally been based on their binding affinity. New techniques and advancements in combinatorial antibody libraries have made it possible to isolate functional antibodies wit...

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Bibliographic Details
Published in:Israel journal of chemistry 2023-10, Vol.63 (10-11), p.n/a
Main Authors: Lin, Chih‐Wei, Ho Han, Kyung
Format: Article
Language:English
Subjects:
Agonist antibody
Combinatorial analysis
Combinatorial antibody library
In vivo selection
Libraries
Monoclonal antibodies
Phage display
Receptors
Stem cells
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Summary:Monoclonal antibodies (mAbs) have become important classes in biopharmaceutical products. The selection of antibodies has traditionally been based on their binding affinity. New techniques and advancements in combinatorial antibody libraries have made it possible to isolate functional antibodies within cellular environments. These antibodies can act an agonist or antagonist provide valuable insights into the complexities of signal transduction and potentially leading to different cell responses or affecting cell behavior. Additionally, an in vivo selection system is utilized, which relies on cell migration to specific tissues, to generate antibodies that induce cells to differentiate and selectively migrate to particular tissues. Overall, the discovery of functional antibodies from antibody libraries has the potential to reveal receptor pleiotropism and pave opportunities to investigate cellular biology and uncover surprising discoveries in the areas of stem cells and cancer research.
ISSN:0021-2148
1869-5868
DOI:10.1002/ijch.202300050