Comparison of IGF-1, IGFBP-3, and Estradiol Levels in Cyst Fluid and Serums of Postmenopausal Women with Benign and Malignant Tumor

[LANGUAGE= "English"] Purpose: Ovarian cancer is the most significant cause of morbidity and mortality among gynecologic cancers. Recently, effects of sex steroids and IGF/IGFBP system, which are the most important risk factors of ovarian cancer, has been investigated. In the present study...

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Published in:Journal of Clinical Practice & Research 2008-01, Vol.30 (1), p.19
Main Authors: Ceren Dinçer Ata, Serin, Ibrahim Serdar, Tanrıverdi, Fatih, Ünlühızarcı, Kürşat
Format: Article
Language:English
Subjects:
Cysts
Hypotheses
Menstruation
Ovarian cancer
Tumors
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Summary:[LANGUAGE= "English"] Purpose: Ovarian cancer is the most significant cause of morbidity and mortality among gynecologic cancers. Recently, effects of sex steroids and IGF/IGFBP system, which are the most important risk factors of ovarian cancer, has been investigated. In the present study, we compared the IGF-1, IGFBP-3, and estradiol levels in cyst fluid and serums of postmenopausal women with benign and malignant ovarian tumor.Materials and Methods: In total, 28 patients,12 patients with malignant ovarian tumor and 16 patients with benign ovarian tumor, were included in the study. In order to minimize the hormonal changes taking place during menstrual cycle, only postmenopausal patients were included in the present study. IGF-1, IGFBP-3, and estradiol levels were measured in cyst fluid and serums.Results: Estradiol level in cyst fluid of patients with malignant ovarian tumor, was significantly high. IGF-1 and IGFBP-3 levels measured in cyst fluid and serums, did not show a significant difference between patients with benign and malignant ovarian tumors.Conclusion: The present study supported the hypothesis proposing an association between estradiol and ovarian carcinogenesis. Further studies are required to understand the importance of microenvironment during tumor growth.
ISSN:2980-2156