An efficient organopromotor L‐arginine facilitated synthesis of thiazolopyrimidine derivatives in EtOH:H2O solvent

An efficient, one pot, multicomponent, L‐arginine catalyzed synthesis of thiazolo[3,2‐a]pyrimidines is described. L‐arginine is an easily available, biodegradable, inexpensive, promising bio‐organic molecule. The current strategy is the first example of amino acid promoted, green synthesis of a seri...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2023-12, Vol.60 (12), p.1976-1988
Main Authors: Sharma, Amit Kumar, Jaiswal, Anjali, Mishra, Anu, Jaiswal, Shweta, Bartendu Pati Tripathi, Singh, Jaya, Singh, Jagdamba
Format: Article
Language:English
Subjects:
Amino acids
Chemical synthesis
Organic chemistry
Pyrimidines
Recyclability
Substrates
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Summary:An efficient, one pot, multicomponent, L‐arginine catalyzed synthesis of thiazolo[3,2‐a]pyrimidines is described. L‐arginine is an easily available, biodegradable, inexpensive, promising bio‐organic molecule. The current strategy is the first example of amino acid promoted, green synthesis of a series of thiazolo[3,2‐a]pyrimidines via the formation of CN and CC bonds. The major advantages of the present methodology such as recyclability of catalyst, operational simplicity, easy scale‐up, wide substrate scope, easy work‐up, inexpensive, excellent yields, and high atom economy make it a distinct improvement over the prevailing strategies.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4730