Photoredox Synthesis of Silyl Ethers via Radical Coupling of Ketones with Hydrosilanes and [1, 2]‐Brook Rearrangement

An expedient synthesis of silyl ethers is reported via photocatalytic free radical coupling of ketones with hydrosilanes and subsequent [1, 2]‐Brook rearrangement. This strategy features the advantages of 100 % atom economy, environmental friendliness, easily available starting materials as well as...

Full description

Saved in:
Bibliographic Details
Published in:European journal of organic chemistry 2023-12, Vol.26 (46), p.n/a
Main Authors: Wang, Ting, Wang, Guo‐Qin, Zhang, Yue, Liu, Yuan‐Yuan, Zhang, Zheng‐Bing, Han, Pan, Jing, Lin‐Hai
Format: Article
Language:English
Subjects:
atom economy
Coupling
Ethers
Free radicals
hydrosilane
Ketones
photocatalysis
radical coupling
silyl ether
Synthesis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An expedient synthesis of silyl ethers is reported via photocatalytic free radical coupling of ketones with hydrosilanes and subsequent [1, 2]‐Brook rearrangement. This strategy features the advantages of 100 % atom economy, environmental friendliness, easily available starting materials as well as late‐stage functionalization of complex molecules. An expedient and straightforward methodology for the synthesis of silyl ethers has been developed, via a visible light‐promoted free radical coupling of ketones with hydrosilanes and subsequent [1, 2]‐Brook rearrangement.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202301087