Serum Trimethylamine N-Oxide, Choline, Betaine, and Carnitine levels among Coronary Artery Disease patients

Background and aimRecent studies have linked Trimethylamine N-oxide (TMAO) to cardiovascular diseases; our study aimed to analyze the association between coronary artery disease (CAD) and TMAO.MethodsPubMed, Scopus, Embase, and Web of Science were searched using terms; such as “CAD” and “TMAO”. Only...

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Published in:The American heart journal 2024-01, Vol.267, p.139-140
Main Authors: Dean, Yomna E., Sabry, Samah S., Talat, Nesreen Elsayed, Ramadan, Alaa, Verma, Suman, Kamdi, Zainab, Gir, Deepak, Helmy, Ahmed, Helmy, Zakaria, Afzal, Ahson, Mady, Tamer, Hazimeh, Yusef, Aiash, Hani
Format: Article
Language:English
Subjects:
Betaine
Cardiovascular disease
Cardiovascular diseases
Carnitine
Choline
Coronary artery disease
Coronary vessels
Heart diseases
Metabolites
Sensitivity analysis
Trimethylamine
Vein & artery diseases
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Summary:Background and aimRecent studies have linked Trimethylamine N-oxide (TMAO) to cardiovascular diseases; our study aimed to analyze the association between coronary artery disease (CAD) and TMAO.MethodsPubMed, Scopus, Embase, and Web of Science were searched using terms; such as “CAD” and “TMAO”. Only observational controlled studies were included. RevMan software version 5.4 was used for the analysis.ResultsA significant association was found between the CAD group and increased serum TMAO levels compared with the control group (MD = 1.16, 95% CI = 0.54 to 1.78, p-value =0.0003). This association remained significant among acute coronary syndrome (ACS) patients (MD=0.98, 95% CI =0.73 to 1.23, p-value
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2023.08.054