13,14-Dehydro-16-phenoxy-PGB1 Ethyl Esters: Synthesis and Some Properties

1,2-Addition reaction of ethyl (5-oxocyclopent-1-enyl)heptenoate with 3-trimethylsiloxy-4-phenoxy-1-butyne lithium derivative followed by oxidative allyl rearrangement afforded cytotoxic ethyl ester of 13,14-dehydro-16-phenoxy derivative PGB 1 .

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Bibliographic Details
Published in:Russian journal of general chemistry 2023-11, Vol.93 (Suppl 1), p.S137-S142
Main Authors: Shavaleeva, G. A., Ivanova, N. A., Utemisova, A. K., Miftakhov, and M. S.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Ethyl esters
Lithium
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Description
Summary:1,2-Addition reaction of ethyl (5-oxocyclopent-1-enyl)heptenoate with 3-trimethylsiloxy-4-phenoxy-1-butyne lithium derivative followed by oxidative allyl rearrangement afforded cytotoxic ethyl ester of 13,14-dehydro-16-phenoxy derivative PGB 1 .
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223140207