Synthesis and Study of New Anticoagulant Candidates Based on 6-Aryl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones

ction of 6-aryl-5,6-dihydro-4 H -pyrrolo[3,2,1- ij ]quinoline-1,2-diones with 3-acetylcoumarins led to the formation of a new series of 1-[2-oxo-2-(2-oxo-2 H -chromen-3-yl)ethylidene]-6-aryl-5,6-dihydro-4 H -pyrrolo[3,2,1- ij ]quinoline-2(1 H )-ones. Primary in vitro screening of anticoagulant activ...

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Bibliographic Details
Published in:Russian journal of general chemistry 2023-11, Vol.93 (Suppl 1), p.S115-S123
Main Authors: Skoptsova, A. A., Novichikhina, N. P., Kosheleva, E. A., Baranin, S. V., Podoplelova, N. A., Panteleev, M. A., Shikhaliev, Kh. S.
Format: Article
Language:English
Subjects:
Anticoagulants
Aromatic compounds
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Coagulation
Quinoline
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Summary:ction of 6-aryl-5,6-dihydro-4 H -pyrrolo[3,2,1- ij ]quinoline-1,2-diones with 3-acetylcoumarins led to the formation of a new series of 1-[2-oxo-2-(2-oxo-2 H -chromen-3-yl)ethylidene]-6-aryl-5,6-dihydro-4 H -pyrrolo[3,2,1- ij ]quinoline-2(1 H )-ones. Primary in vitro screening of anticoagulant activity against coagulation factors Xa and XIa was performed for all target compounds. The IC 50 value was also determined for the structures that showed the highest inhibition values among synthesized molecules.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223140359