Monitoring Melanoma Responses to STING Agonism and Focused Ultrasound Thermal Ablation Using Microneedles and Ultrasensitive Single Molecule Arrays (Adv. Funct. Mater. 50/2023)

Ultrasensitive Single Molecule Arrays In article number 2301659, Natalie Artzi and co‐workers show that engineered polymeric microneedles enable sampling of biomarkers in skin interstitial fluid in response to melanoma treatment with combination immunoablative therapy—focused ultrasound thermal abla...

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Bibliographic Details
Published in:Advanced functional materials 2023-12, Vol.33 (50), p.n/a
Main Authors: Dahis, Daniel, Dion, Michelle Z., Cryer, Alexander M., Dosta, Pere, Gilboa, Tal, Alonso, Mariana, Lewandowski, Michael, Puigmal, Núria, Taboada, Gonzalo Muñoz, Azhari, Haim, Ahmad, Rushdy, Walt, David R., Artzi, Natalie
Format: Article
Language:English
Subjects:
Ablation
Arrays
Biomarkers
focused ultrasound thermal ablation
ISF biomarkers
Materials science
melanoma
microneedles
nanoparticles
Needles
Simoa
Stimulators
STING
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Summary:Ultrasensitive Single Molecule Arrays In article number 2301659, Natalie Artzi and co‐workers show that engineered polymeric microneedles enable sampling of biomarkers in skin interstitial fluid in response to melanoma treatment with combination immunoablative therapy—focused ultrasound thermal ablation and nanoparticulate stimulator of interferon genes agonism. Subsequent microneedle‐derived biomarker processing via ultrasensitive single‐molecule arrays afford effective detection of proinflammatory biomarkers in the femtomolar range.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202370295