Lipid Nanoparticles for Lutein Encapsulation and Delivery

Recently, lipid nanoparticles have been intensively studied as carriers of lipophilic drugs. In this work, we have studied the stability of nanoemulsions with paraffin oil, solid lipid nanoparticles with stearic acid, and nanostructured lipid particles with paraffin oil and stearic acid in a mass ra...

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Bibliographic Details
Published in:Colloid journal of the Russian Academy of Sciences 2023-10, Vol.85 (5), p.817-826
Main Authors: Shirokikh, A. D., Guruleva, Y. A., Marinets, E. A., Koroleva, M. Y.
Format: Article
Language:English
Subjects:
Bioavailability
Blood flow
Chemistry
Chemistry and Materials Science
Drugs
Flow velocity
Hypoxia
Lipids
Lipophilicity
Lutein
Nanoemulsions
Nanoparticles
Nanostructure
Paraffins
Polymer Sciences
Restoration
Stability
Stearic acid
Surfaces and Interfaces
Thin Films
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Summary:Recently, lipid nanoparticles have been intensively studied as carriers of lipophilic drugs. In this work, we have studied the stability of nanoemulsions with paraffin oil, solid lipid nanoparticles with stearic acid, and nanostructured lipid particles with paraffin oil and stearic acid in a mass ratio of 1 : 1. The obtained results have shown that all studied lipid systems stabilized with nonionic surfactants Tween 60 and Span 60 were stable to aggregation and subsequent sedimentation for more than 30 days. The incorporation of lutein into the lipid particles has almost no effect on their stability, while the size of solid lipid nanoparticles and nanostructured lipid nanoparticles decreases from 28–30 to 15–17 nm. The bioavailability of lutein loaded in lipid nanoparticles is evaluated from their effect on the restoration of blood flow velocity by simulating hemic hypoxia. Almost immediately after the application of lipid nanoparticles, the blood flow velocity ceases to decrease, and a tendency to its restoration is observed in 5–10 min. This shows that lipid nanoparticles with paraffin oil and stearic acid are promising candidates for the delivery of lipophilic drugs.
ISSN:1061-933X
1608-3067
DOI:10.1134/S1061933X2360063X