Nuclear PARP1‐Targeted Photosensitizer as a Dual‐Mode DNA‐Damaging Agent and Immune Activator for Tumor Ablation (Adv. Healthcare Mater. 31/2023)

Photosensitizers In article number 2301517, Guiling Li, Gang Shan, and co‐workers design a nuclear PARP1‐targeted photosensitizer PARP‐PS based on the reported PARP1 inhibitor rucaparib. As a dual‐mode DNA‐damaging agent, PARP‐PS damages DNA upon photoirradiation and enhances oxidative DNA damage by...

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Bibliographic Details
Published in:Advanced healthcare materials 2023-12, Vol.12 (31), p.n/a
Main Authors: Li, Peixia, Du, Yayin, Qiu, Jingru, Li, Donghai, Li, Guiling, Shan, Gang
Format: Article
Language:English
Subjects:
Ablation
Anticancer properties
Antitumor activity
Damage
DNA damage
DNA repair
Poly(ADP-ribose) polymerase
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Summary:Photosensitizers In article number 2301517, Guiling Li, Gang Shan, and co‐workers design a nuclear PARP1‐targeted photosensitizer PARP‐PS based on the reported PARP1 inhibitor rucaparib. As a dual‐mode DNA‐damaging agent, PARP‐PS damages DNA upon photoirradiation and enhances oxidative DNA damage by blocking the DNA repair pathway via PARP1 inhibition and degradation, thus exhibiting excellent antitumor efficacy.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202370204