The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery

In order to precisely deliver celastrol into mitochondria of tumor cells, improve antitumor efficacy of celastrol and overcome its troublesome problems in clinical application, a novel multistage-targeted celastrol delivery system (C-TL/HA) was developed via electrostatic binding of hyaluronic acid...

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Bibliographic Details
Published in:Drug delivery 2023-12, Vol.30 (1), p.2162156-2162156
Main Authors: Xiao, Simeng, Huang, Siying, Yang, Xiaojing, Lei, Yujie, Chang, Mingxiang, Hu, Junjie, Meng, Yan, Zheng, Guohua, Chen, Xinyan
Format: Article
Language:English
Subjects:
anticancer effect
Apoptosis
Celastrol
Cell Line, Tumor
Chinese medicine
Cholesterol
delivery system
Drug delivery systems
Drug Delivery Systems - methods
Hyaluronic acid
Hyaluronic Acid - chemistry
Laboratory animals
Liposomes - chemistry
Liver cancer
Mitochondria
mitochondrial targeting
Pentacyclic Triterpenes - pharmacology
tumor targeting
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Summary:In order to precisely deliver celastrol into mitochondria of tumor cells, improve antitumor efficacy of celastrol and overcome its troublesome problems in clinical application, a novel multistage-targeted celastrol delivery system (C-TL/HA) was developed via electrostatic binding of hyaluronic acid (HA) to celastrol-loaded cationic liposomes composed of natural soybean phosphatidylcholine and cholesterol modified with mitochondrial targeting molecular TPP. Study results in this article showed that C-TL/HA successfully transported celastrol into mitochondria, effectively activated apoptosis of mitochondrial pathway, exerted higher tumor inhibition efficiency and lower toxic side effects compared with free celastrol. More importantly, HA coating not only enabled this delivery system to have good stability and safety in vivo, but also increased drug uptake and facilitated tumor targeting through recognizing CD44 receptors rich on the surface of tumor cells. Conclusively, this HA-coated mitochondrial targeting liposomes may provide a prospect for the clinical application of celastrol in tumor therapy.
ISSN:1071-7544
1521-0464
DOI:10.1080/10717544.2022.2162156