Zinc(II) Complex with 2-Hydroxy-5-ethylphenylphosponic Acid: Synthesis, Structure, Toxicity, and Accumulation in HeLa Cells

A complex of zinc(II) with 2-hydroxy-5-ethylphenylphosphonic acid (H 3 L) of the composition [Zn(H 2 L) 2 (Н 2 О) 2 ][Zn(HL)(Н 2 О)]·H 2 O ( I ) was synthesized, the structure of which was established based on data of X-ray diffraction and elemental analysis, quantum chemical calculations, as well a...

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Bibliographic Details
Published in:Russian journal of inorganic chemistry 2023-08, Vol.68 (8), p.995-1004
Main Authors: Ivanova, I. S., Tsebrikova, G. S., Ilyukhin, A. B., Solov’ev, V. P., Lapshina, M. A., Rogacheva, Yu. I., Pyatova, E. N., Baulin, V. E., Tsivadze, A. Yu
Format: Article
Language:English
Subjects:
Accumulation
Chemical analysis
Chemistry
Chemistry and Materials Science
Coordination Compounds
Inorganic Chemistry
Quantum chemistry
Stability constants
Titration
Zinc compounds
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Summary:A complex of zinc(II) with 2-hydroxy-5-ethylphenylphosphonic acid (H 3 L) of the composition [Zn(H 2 L) 2 (Н 2 О) 2 ][Zn(HL)(Н 2 О)]·H 2 O ( I ) was synthesized, the structure of which was established based on data of X-ray diffraction and elemental analysis, quantum chemical calculations, as well as IR and electron absorption spectroscopies. The stability constants of H 3 L acid complexes with zinc(II) perchlorate in water were determined by potentiometric titration. The cytotoxic properties of H 3 L acid and complex I were studied for the first time on HeLa cells (human cervical adenocarcinoma). The results on the accumulation of complex I in HeLa cells were obtained by laser confocal microscopy.
ISSN:0036-0236
1531-8613
DOI:10.1134/S0036023623601393