Residue dissipation and dietary risk assessment of cyazofamid and its metabolite CCIM in garlic, garlic bolt and garlic sprout

• Published in: International journal of environmental analytical chemistry 2023-12, Vol.103 (20), p.8914-8927
• Main Authors: Shuaibing, Han, Miao, Yu, Wen, Xue, Yaozhong, Zhang, Yayu, Wu, Li, Zhou
• Format: Article
• Language: English
• Subjects: CCIM; Chromatography; Cyazofamid; Diet; Dietary intake; dietary risk assessment; Dissipation; Field tests; Food intake; Garlic; High performance liquid chromatography; HPLC; Kinetic equations; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Metabolites; residue; Residues; Risk assessment
• ISSN: 0306-7319; 1029-0397
• DOI: 10.1080/03067319.2021.1998477

The residue and dissipation dynamics of cyazofamid and its main metabolite 4-chloro-5-p-tolylimidazole-2-carbonitrile (CCIM) in garlic, garlic bolt and garlic sprouts were investigated by QuEChERS high-performance liquid chromatography-tandem mass spectrometry method. Field experiments were conducted in 6 sites for one year. The dietary intake risk of cyazofamid was assessed. At different levels, the results showed that the average recoveries of cyazofamid were 89.8%-1005% in garlic, 84.6%-109.4% in garlic bolt and 88.6%-108.5% in garlic sprout, recoveries of CCIM were 84.6%-104.2% in garlic, 84.6%-108.9% in garlic bolt and 85.3%-109.2% in garlic sprout, respectively, with relative standard deviation less than 10.1%. The limits of quantitation were all 0.01 mg/kg. The dissipation dynamics of cyazofamid and CCIM in garlic plant matrices fitted the first order kinetic equation, and the half-lives were 3.5-6.1 d and 0.9-3.9 d, respectively. The dietary intake risk assessment showed that the dietary exposure risk index of cyazofamid in garlic, garlic bolt and garlic sprout were less than 100%, which indicated that the dietary exposure risk was at an acceptable level.