The Gut as a Potential Centerpiece in Fructose-Driven Dysmetabolism

Purpose of Review Non-exhaustively and critically discuss recent advances in the understanding of fructose-induced dysmetabolism with a focus on the gut. We also highlight key knowledge gaps and present novel research perspectives on this topic. Recent Findings Excess fructose is detrimental to meta...

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Bibliographic Details
Published in:Current molecular biology reports 2023, Vol.9 (4), p.44-51
Main Authors: Sellami, Eya, Anhê, Gabriel Forato, Douard, Véronique, Anhê, Fernando Forato
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Digestive system
Fructose
Gastrointestinal tract
Human Genetics
Liver
Metabolic disorders
Molecular Medicine
Topical Collection on Molecular Mechanisms in Endocrine Tissues
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Summary:Purpose of Review Non-exhaustively and critically discuss recent advances in the understanding of fructose-induced dysmetabolism with a focus on the gut. We also highlight key knowledge gaps and present novel research perspectives on this topic. Recent Findings Excess fructose is detrimental to metabolic health and risk for metabolic diseases, but the elements connecting excess fructose to dysmetabolism remain ill-defined. The liver is seen as the key organ in the pathophysiology of fructose-driven metabolic disease. However, new evidence positions the gut as another important contributor. The gut shields the liver from fructose. When fructose exceeds intestinal clearance capacity, it overflows to the liver and distal gut. How fructose buildup in the gut lumen contributes to metabolic disease is not well-understood. Summary Shedding light onto the enteric determinants of fructose-driven dysmetabolism can lead to new strategies to alleviate metabolic diseases.
ISSN:2198-6428
2198-6428
DOI:10.1007/s40610-023-00156-3