The Types and Applications of Peptibodies

Peptides as drugs are a promising therapeutic method. Peptides modulate diverse biological processes and are synthesized with high purity. Due to their low cell permeability, peptide drugs target extracellular receptors. The peptibody comprises the biologically active Fc region and the peptide itsel...

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Bibliographic Details
Published in:International journal of peptide research and therapeutics 2023-12, Vol.30 (1), p.6, Article 6
Main Authors: Nemati, Mohammadmahdi, Ahmadi, Ahmadreza, Hashemzehi, Ahmad, Nasrullozoda, Farukhruzi, Abedi, Mohsen, Hashemzaei, Masoud
Format: Article
Language:English
Subjects:
Angiogenesis
Animal Anatomy
Biochemistry
Biological activity
Biomedical and Life Sciences
Cancer therapies
Cell permeability
Chemical synthesis
Clinical trials
Cytotoxicity
Dimerization
Drugs
FDA approval
Growth factors
Histology
Life Sciences
Medical research
Molecular Medicine
Monoclonal antibodies
Morphology
Peptides
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Polymer Sciences
Proteins
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Summary:Peptides as drugs are a promising therapeutic method. Peptides modulate diverse biological processes and are synthesized with high purity. Due to their low cell permeability, peptide drugs target extracellular receptors. The peptibody comprises the biologically active Fc region and the peptide itself. Various peptides with specific biological activities have been successfully fused into the Fc region. These peptide-Fc fusions, also known as peptibodies, offer an excellent therapeutic alternative to monoclonal antibodies. They comprise biologically active peptides bound to the Fc region. This approach retains antibodies' beneficial characteristics, especially the enhanced affinity resulting from Fc dimerization and extended plasma residence time. Peptibodies can be produced in Escherichia coli using recombinant methods. In this study, we describe peptibodies and analyze different types of peptibodies collected for research.
ISSN:1573-3904
1573-3149
1573-3904
DOI:10.1007/s10989-023-10582-7