Lymphocytic Panhypophysitis Mimicking Glaucoma: Case Report

• Published in: Case reports in ophthalmology 2023-01, Vol.14 (1), p.319-325
• Main Authors: Keys, Phillip Howard, Hunt, Patrick J, Anozie, Clement, Cayenne, Samir, Davila-Siliezar, Pamela, Laylani, Noor, Lee, Andrew G
• Format: Article
• Language: English
• Subjects: autoimmune; Biopsy; Case Report; Case reports; Defects; Diabetes; Diplopia; Family medical history; Glaucoma; Headaches; Hypertension; Hypothyroidism; Inflammation; Lasers; lymphocytic hypophysitis; lymphocytic panhypophysitis; Magnetic resonance imaging; Motility; Ophthalmology; Patients; Polyuria; Pregnancy; Thyroid gland; Visual acuity
• ISSN: 1663-2699; 1663-2699
• DOI: 10.1159/000531445

Abstract Lymphocytic hypophysitis (LH) is a primary inflammatory disorder of the pituitary gland and infundibulum that commonly manifests in both mass effect and endocrinologic symptoms. Although the exact pathophysiology remains unclear, it has been increasingly linked to an autoimmune process. Complications arise by two separate mechanisms. Inflammation in the sella can lead to headaches and visual field defects. Pituitary inflammation and, chronically, fibrosis interfere with the gland’s hormone-secreting capacity, often resulting in various endocrinopathies such as polyuria, polydipsia, amenorrhea, and others. While final histologic classification requires pathologic evaluation, diagnosis can often be made clinically with appropriate imaging. Treatment often consists of conservative management but can also include glucocorticoids or surgical resection. We present a case of biopsy-proven LH involving the entire pituitary, dubbed lymphocytic panhypophysitis (LPH) that was misdiagnosed for years as glaucoma due to the lack of endocrinopathy as well as delay in magnetic resonance imaging. After imaging revealed the sellar mass, the patient responded symptomatically to surgical resection and glucocorticoid treatment. LPH may present without endocrinologic symptoms and therefore mimic alternate diagnoses such as glaucoma. Clinicians should be suspicious of a diagnosis of glaucoma in the setting of a temporal field defect and lack of response to traditional therapy. A personal or family history of autoimmune disease in such patients should prompt further imaging and investigation. Therefore, endocrinopathy is supportive but not present in every case of LPH.