Analysis of Anti-Inflammatory Properties of Plant Oxylipins Produced in the Hydroperoxide Lyase Branch

Short-chain and medium-chain aldehydes and their derivatives, yielded by the enzymes hydroperoxide lyases from fatty acids, are present in many products of plant origin. They are often used as supplements to food to postpone its expiration date and to add a flavor of freshness. Since these compounds...

Full description

Saved in:
Bibliographic Details
Published in:Russian journal of plant physiology 2023-12, Vol.70 (7), p.166-166, Article 166
Main Authors: Radzyukevich, Y. V., Tikhonov, K. G., Degtyaryov, E. A., Degtyaryova, V. I., Savchenko, T. V.
Format: Article
Language:English
Subjects:
Alcohols
Aldehydes
Anti-inflammatory agents
bioactive properties
Biological activity
Biomedical and Life Sciences
blood
Carbon
Chain branching
Dietary supplements
flavor
freshness
human health
Hydroperoxide lyase
Inflammatory diseases
Intestine
intestines
Life Sciences
lyases
oxylipins
Plant Physiology
Plant Sciences
Research Papers
tumor necrosis factor-alpha
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Short-chain and medium-chain aldehydes and their derivatives, yielded by the enzymes hydroperoxide lyases from fatty acids, are present in many products of plant origin. They are often used as supplements to food to postpone its expiration date and to add a flavor of freshness. Since these compounds can be absorbed by the intestine cells and pass into systemic circulation, it is important to be aware of their influence on human health. In the present study, the potential biological activity of aldehydes and alcohols with chains containing six to nine carbon atoms were assessed. Their proinflammatory activities were tested in the experimental system based on donors’ whole blood. It was found that nine-carbon oxylipins stimulated the synthesis of the proinflammatory TNF-α cytokine (tumor necrosis factor alpha), and the stimulation by the aldehydes was weaker than that caused by the alcohols. The oxylipins containing six or eight carbons did not manifest proinflammatory activity. The obtained data may be of help to work out nutritional recommendations for patients suffering from inflammatory diseases.
ISSN:1021-4437
1608-3407
DOI:10.1134/S1021443723700279