Assessment of Antihepatotoxic potential of Sesbania grandiflora fruits extract against Organosulfur compound- thioacetamide induced hepatopathy in experimental rodents

• Published in: Research journal of pharmacy and technology 2023-10, Vol.16 (10), p.4929-4934
• Main Authors: Tathe, Prafulla, P. Uplanchiwar, Vaibhav, M. Hiradeve, Sachin, Yadaorao Raut, Sushil, Katole, Gayatri, Deshmukh, Mayuri, Mane, Namrata, B. Fulzele, Vijendra, Mansoori, Mohd. Hashim
• Format: Article
• Language: English
• Subjects: Animals; Cholesterol; Drug dosages; Flavonoids; Liver; Phytochemicals; Proteins; Toxicity
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.52711/0974-360X.2023.00799

While dealing with the herbal drugs for various chaoses, flavonoids and saponin established their position and hepatoprotection is fine example among all health related issues. So, the study was executed taking into considerations of edible herbal constituents to check the potency of fruits extract of Sesbania grandiflora (FESG) on thioacetamide induced hepatotoxicity in experimental animals. In experimentation, the petroleum ether (PE) extracts at 100, 200 and 400mg/kg/p.o was fed to rats before intoxicated with thioacetamide (100 mg/kg). To check the efficacy of plant material, the diverse factors were assessed like SGOT, SGPT, SALP, bilirubin, protein, cholesterol, albumin and triglyceride and to confirm the study, liver histopathology was also determined. The obtained result parameters authenticated the strength of plant material via assessed factors with endorsement by histopathological study. The shielding outcome of this extract was due to the occurrence of phenol, flavonoids, and various antioxidants and due to existence of quercetin in it.