Compression of Genetic Expression of Progesterone and Prostaglandin E2 Between PCOS and Non-PCOS Women

• Published in: Research journal of pharmacy and technology 2023-10, Vol.16 (10), p.4781-4785
• Main Authors: B. Sharafaldeen, Sura, Abou-El-Naga, Amoura M., Al-Dujialy, Saad S., Badawy, Ahmed
• Format: Article
• Language: English
• Subjects: Endometrium; Estrogens; Gene expression; Growth factors; Ligands; Ovaries; Polycystic ovary syndrome; Pregnancy
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.52711/0974-360X.2023.00775

Several hormones may interact with the implantation process by mobilizing several molecular modulators in a spatiotemporal manner. A total of 31 women were selected intentionally, then divided into (16) with polycystic ovarian syndrome and (15) healthy women with male factor, the blood serum samples were analyzed by real-time quantitativepolymerase chain reaction (RT- qPCR) for measurement of the fold of expression for Progesterone (P4) and Prostaglandin (PGE2) in the day of ova pick up (OPU) and after 14 days of embryo transfer (ET) in pregnant and non-pregnant women for PCOS and Non-PCOS groups. The results showed that there were no statically significant differences encountered between non-PCOS andPCOS groups in the expression of progesterone and prostaglandin genes (P 0.7296) and ( P 0.0530) respectively. Conclusion: 1- P4 and COX-2 expression in women PCOS is less common in healthy women than in menopausal women. 2- COX-2 is one of the indicators to consider in the case of blastocyst adhesion to the uterine wall.3-In both the PCOS and non-PCOS groups, there was a small increase in P4 and PGE2 expression on the day of ova collection and after 14 days after embryo transfer.