Mathematical Model of Insulin-like growth factor-1 estimating its cause in human bone cancer arises due to liver cancer

• Published in: Research journal of pharmacy and technology 2023-09, Vol.16 (9), p.4199-4205
• Main Authors: Kandula, Ramanamoorthy, S. Jain, Rupali, Kandula, Sandhya, Reddy, B. Surendranath
• Format: Article
• Language: English
• Subjects: Bone cancer; Bones; Cell growth; Circulatory system; Design; Insulin; Insulin-like growth factors; Kinetics; Liver cancer; Mathematical models; Metastasis; Ordinary differential equations; Peptides; Plasma; Simulation
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.52711/0974-360X.2023.00687

The insulin-like growth factor-1 (IGF-1) is a peptide hormone that is regulated by growth hormone and secreted in the liver; its prime role is to regulate the growth and proliferation of the bone cell. Our study results relate to the cause of bone cancer due to high IGF-1 levels in liver metastatic conditions. Liver cancer increases the liver volume which further increases IGF-1 secretion to a toxic level, which in turn causes uncontrolled bone cell proliferation and maturation thus leading to bone cancer. Thus, the mathematical model was designed to explain the kinetics of IGF-1 from the liver to bone and mathematically simplified using the ordinary differential equation, and IGF-1 concentration was estimated in the normal and cancerous state. The mathematical simulation was done using a high throughput technique using MATLAB (version R2020a). The model parameter condition due to liver cancer is considered as an increase in liver volume (vL), The initial mass of IGF-1(x01), and the varying rate constants (kP, kL, ke1, and ke2). The graphical results represent the volume of the liver and synthesis of IGF-1 increases with varying abnormal rate constants giving the estimation of an increase in IGF-1 concentration in plasma, and more IGF-1 deposits over the bone to a toxic level.